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In spite of this, it has proved difficult to analyse a biological downstream effect of increasing ATRA concentrations, due to the RA-mimetic effects of acitretin itself.
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Despite their importance, flight recorders and cockpit voice recorders have proved difficult to justify by certain cost-benefit analyses, Mr. Hall said.
It proved difficult to recruit homes for the study.
Despite their apparent universality, it proved difficult to derive biological conclusions from the patterns discovered in these initial global statistical analyses of molecular interaction networks.
Genocide has proved difficult to prosecute.
The effect proved difficult to measure.
Neutrality proved difficult to maintain, though.
Alas, it proved difficult to find.
Yet reform proved difficult to implement.
The furlough plan proved difficult to enforce.
The advice proved difficult to follow.
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