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Large scale culture of marine dinoflagellate microalgae has proved difficult owing to their extreme sensitivity to hydrodynamic forces in photobioreactors.
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The disease classification has proven difficult owing to the varying histologic appearance and clinical behavior of MNA that metastasize to the peritoneal surfaces [ 2].
Obtaining single images through the same plane of section in a cell has proven difficult owing to the rapid z-axis movement of a swelling slice and in general does not fully capture the borders of a typical astrocyte soma.
Daily quality control entails running "normal blood samples" in conjunction with the commercial control beads, and laboratories usually rely on donors to obtain normal samples; this may prove difficult owing to the need to find a donor on a day-to-day basis.
The use of SBML seemed appropriate only when the emphasis would have been on quantification of cooperative interaction models for simulation, which is beyond our scope for now and might prove difficult owing to the limited availability of quantitative cooperative interaction data and appropriate models.
As a result, RTK-targeting therapies have been initiated but proved difficult, mainly owing to the multiplicity of dysregulated RTKs.
Achieving a random sample of subjects in this field setting would prove very difficult owing to the widely dispersed nature of these semi-urban communities, and to the restricted age group being studied.
Achieving a random sample of study participants in this field setting would prove very difficult owing to the widely dispersed nature of these semi-urban communities, and to the restricted age group being studied.
The new coins proved difficult to produce; owing to the hardness of the planchet, the coins were not of high quality and the life of the striking dies was brief.
Harvesting tunichromes tailored with the pyrogallol moiety are extremely difficult owing to aerial sensitivity and purification difficulties, thus proving a challenging synthesis problem.
Blinding of participants and researchers tends to be difficult owing to the nature of interventions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com