Sentence examples for proved deleterious from inspiring English sources

Finally, reversal of one of the central amide bonds as in series 13 proved deleterious to the inhibitory activity.

Introduction of a 17α-benzyl substituent to such 2-substituted estrogen sulfamates also proved deleterious to anti-proliferative activity but could, in one case, enhance STS inhibition with respect to the parent substituted estrone sulfamate.

It is possible that the initial processingof skin and environmental samples at 30°C, a temperature that is optimal for recovery of human and animal pathogenic fungi, proved deleterious to any G. destructans that was present in these samples.

Because formaldehyde fixation proved deleterious to PAR1 immunostaining (see Results below), the bladder of one additional rat was collected under halothane anesthesia, frozen in liquid nitrogen and stored for immunohistochemistry (described below).

For example, the Shoemaker approach was forcefully marketed towards managing established severe sepsis and shock, yet, when formally challenged, its use proved deleterious in a dose-dependent manner [ 6].

Hence, it is deduced that Pd/Pt electrocatalysts utilising Nafion membranes should not prove deleterious to electrocatalytic activity.

Many valuable compounds, or the intermediates necessary for their biosynthesis, prove deleterious at the desired production concentrations.

Initially we were concerned that the silencing of this receptor might prove deleterious.

Endothelin receptor blockers, however, have been proven deleterious as a prophylactic tool against CIN [ 226].

However, endothelin Receptor Blockers have been proven deleterious as a prophylactic tool against contrast-induced AKI [ 196].

Hg has proven deleterious effects on male reproductive system that have been extensively investigated over the past years [ 9, 10].