In a recent year-long study, brimonidine tartrate gel 0.5% applied once daily proved to be both efficacious and safe, regardless of the presence of concomitant therapies.
In conclusion, dexrazoxane proved highly efficacious and tolerable in the management of accidental anthracycline extravasation.
In general, both routes have proved efficacious and are being routinely employed by stem cell researchers.
PREP and circumcision are two biomedical HIV prevention interventions respectively – one which has generated a significant amount of interest but is yet to be proven efficacious and the other which has been proven to be efficacious, but has been met with some controversy in specific settings.
Although systemic MSC administration has proven efficacious and has a large advantage as our above previous studies [11, 12], possible risks, including pulmonary embolism, pose a serious issue [13, 14].
There is not a chemical entity that failed human clinical trials that did not at first prove efficacious and safe in animals: All animals - rats, rabbits, dogs, pigs, not just the oft-mentioned mouse.
However, studies have also demonstrated the administering the first dose of the rotavirus vaccine in the neonatal period proves efficacious and affords protection early on in life [ 40].
Although clinical trials conducted in real world settings involve complex strategies, decisions and tradeoffs, interventions tested in the setting intended for its use may have greater potential for rapid implementation and sustainability if proven efficacious and cost effective.
IncobotulinumtoxinA (Xeomin, NT 201, Merz Pharmaceuticals GmbH, Germany) treatment has been proven efficacious and well tolerated in patients with CD 8 10 and preliminary results also indicate a low antigenicity.
The current study, together with previous randomized trials, suggests that e-cigarettes may prove to be both an efficacious and effective aid to smoking cessation [ 10, 11].
