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Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging.
Recent data proved activity against Pseudomonas aeruginosa superior to that of cefepime [ 16, 17].
Based on the proved activity of the heme prosthetic group of oxidative enzymes in the oxidative couplings of humic phenols [16, 17], the use of much more resilient biomimetic catalysts, such as biocompatible metal-porphyrins, can be employed to promote an effective oligo-/polymerization of the phenolic components of humus [18, 19].
Literature data mining reveals 49 compounds with experimentally proved activity against Ebola virus infection (Table 1).
Of note is that five of six antibiotics with experimentally proved activity against Ebola virus infection (azthromycin, erythromycin, spiramycin, dirithromycin, charitromycin) are macrolides.
A fixed UFT dose of 250 mg m−2 day−1 for 28 days was chosen on the basis of the proved activity and tolerability of continuous administration and the results of previous phase I/II studies (Twelves, 1999; Price and Hill, 2000; Vanhoefer and Wilke, 2001).
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Are there reasons to believe that a proven activity will be well suited and effective in a new location?
CSE-1034 is a novel antibiotic adjuvant entity (AAE) with proven activity against broad range of multi-drug resistant (MDR) pathogens causing various bacterial infections.
The epidermal growth factor receptor monoclonal antibody cetuximab has proven activity in metastatic colorectal cancer.
The epidermal growth factor receptor (EGFR) mAB cetuximab has proven activity in metastatic colorectal cancer.
Gemcitabine is a cytidine nucleoside analogue with proven activity in advanced breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com