Sentence examples for proved active in from inspiring English sources
The use of a broad range of commercially available phenols quickly identified compounds which proved active in cells.
In conclusion, biweekly instillation of Gem proved active in BCG-refractory Ta G3, T1 G1-3 TCC.
Temozolomide in combination with the PARP inhibitor AG-014700 proved active in medulloblastoma xenografts, with sustained tumor regression being achieved in the D425Med MGMT-negative model [167].
Similarly, irinotecan as a monotherapy proved active in children with relapsed CNS tumors, producing partial or complete responses in subsets of glioma [211] and medulloblastoma patients [212], and objective responses in children with recurrent medulloblastoma when combined with bevacizumab [213].
Topoisomerase poisons such as irinotecan have been successfully used to treat neuroblastoma patients [112] and proved active in phase I and II trials in combination with temozolomide [138], [139].
Our recently designed A199S/F227A/S287G/A328 W/Y332G mutant of human BChE has a considerably improved catalytic efficiency against -cocaine and has been proven active in vivo.
Stress-assisted grain boundary migration is a mechanism that has proven active in polycrystals but that relies on a limited number of models.
PABA/NO has proven active in several cancer models in vitro and in vivo, but its tendency to be metabolized via a variety of pathways, some that generate inactive metabolites and hydrolysis products, limits its potential as a drug.
Our more recently designed A199S/F227A/S287G/A328W/Y332G mutant of human BChE, denoted as cocaine hydrolase-3 (Cochas, has a considerably improved catalytic efficiency against cocaine and has been proven active in blocking cocaine-induced toxicity and physiological effects.
If mGluR5 represented the target of action of the pyrazolones, known mGluR5 antagonists should prove active in our cell-based assay.
The Bombyx mori actin 3C promoter and Drosophila ubiquitin promoter have proven active in a variety of insect species [ 13] and should be evaluated in Spodoptera insect cell culture as an alternative means to possibly improve transgene expression.
