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The Princeton disaster proved a major setback for Texas annexation, in that Tyler expected Secretary Upshur to elicit critical support from Whig and Democratic Senators during the upcoming treaty ratification process.
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Ardley does not believe that, should they end up dropping into non-league, relegation would prove a major setback to the club.
But still, there is no assurance that all the children in the hard-to-reach areas are safe from polio and this might just prove a major setback in the quest to eradicate the disease.
The reports emerged within days of the resignation of the chief of the Mossad, and only months after a bungled attempt to assassinate a Hamas official in Jordan last fall proved a major embarrassment to Israel and a setback to its relations with Jordan.
The film proved a major commercial success.
This proved to be a major setback for relief operations.
The air coalition dropped on Kobani more than one third of all the ordnance it has used throughout the campaign and proved decisive in the fight, which was a major setback for Isis.
The amended ruling, which clarified a decision that proved to be so confusing that both sides claimed victory, is a major setback for Taubman Centers, which the Simon Property Group, the nation's largest mall owner, wants to buy for $1.74 billion.
In an interview on Friday, a European diplomat familiar with Iran's nuclear program called the fueling problem a major setback, even if the technical cause proves to be less than monumental.
The boycott lasted a year and was a major setback for polio eradication.
Or a major setback for feminism?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com