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Can any of the traditional levers prove tolerable?
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After a scouring shower of rain first thing in the morning, the skies were blue with scudding clouds; and if the November sun did not rise much above the tops of the trees in St. James's Park, where crowds gathered opposite Horse Guards Parade to watch the assembling marchers, the conditions might have proved tolerable even to President Trump.
Vorinostat in combination with lenalidomide and dexamethasone proved tolerable with appropriate supportive care, with encouraging activity observed.
Consolidation chemotherapy proved tolerable in our study and the majority (90.5%) of patients who started consolidation chemotherapy completed 4 cycles of consolidation chemotherapy, as scheduled.
If true, soft chow may prove more tolerable than hard chow, given the lack of enamel.
Alternate dosing schedules for topotecan/cisplatin, or the substitution of carboplatin for cisplatin, might prove more tolerable.
Nine patients were treated in this last cohort, which was twice expanded to further assess feasibility beyond cycle 1 after proving just tolerable in the terms described in the protocol.
Furthermore, while high PMO doses may offer a rapid restitution of dystrophin synthesis, it is most unlikely that, even if these high doses were to prove safe and tolerable, such amounts would be financially sustainable at this time.
Erlewine, who gave the album four and a half out of five stars, commented that while the album "rebounds with songs that prove mechanical can be tolerable if delivered with hooks and panache," it still made Bad feel like an artifact of its time instead a piece of music that transcends it".
As such, focusing research on the identification and management of sarcopenia in patients with lung cancer may prove to be a tolerable and cost-effective adjunct to the current lung cancer care.
In terms of toxicity, the biweekly regimen also proved to be tolerable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com