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Isolated 46-mers from both aaRS classes bind tightly to ATP (KD = 10-65 μM), as has been observed for structurally homologous 45-51 residue fragments isolated from a variety of nucleotide-binding proteins [ 67- 71] containing the Walker-A motif and, by this criterion, may prove to be distant relatives of the Class I aaRS [ 39].
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Distant reading might prove to be a powerful tool for studying literature, and I'm intrigued by some of the lab's other projects, from analyzing the evolution of chapter breaks to quantifying the difference between Irish and English prose styles.
As distant metastases are responsible for patient mortality, miR-124, withethe ability to impede metastasis, may prove to be clinically useful.
Tumours that do not exhibit the self-metastatic phenotype, by contrast, prove to be slow growing and unable to seed stem cells either to areas adjacent to the primary site or to distant sites.
David Carr was the first draft pick of the new franchise, but he proved to be a distant team member, inclined to go home to his family rather than spend extra time bonding with his teammates and studying film.
This was Genevieve Cook, a white Australian, who let Maraniss quote the notes she made during her infatuation with Obama and eventual estrangement — including the judgment that for all his initial charm, he proved to be too cool and distant.
Many of the conserved proteins were also found to be well conserved in the liverwort S. moelledorfii, and some of them even in the moss P. patens, whereas C. reinhardtii proved to be phylogenetically much more distant (Additional file 12: Table S4).
Classification of breast cancer by biologic subtype has proven to be a strong predictor of distant relapse [ 2, 3].
Blast searching for these genes proved to be unfruitful, even when low sensitivity (distant homology) was used.
In 1949, Chinese Communists claimed power in distant Beijing and proved to be a force that the Himalayan mountain kingdom could not overcome.
In the late afternoon of September 28 they sighted a distant sail, which proved to be the Canadian bark Huron, bound for Quebec.
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