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Lord Monk Bretton said that the government's reforms were "a Pandora's box that may prove problematical for the future".
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Although this method provided a basis for many of the assignments, it also proved problematical for assigning some of the closely positioned methyl resonances such as those arising from Ile329 and Ile375.
Methods involving the analysis of nucleic acids have become widespread in the fields of traditional biology and ecology, however the storage and transport of samples collected in the field to the laboratory in such a manner to allow purification of intact nucleic acids can prove problematical.
First, setting a benchmark often proves problematical.
In addition, the observation that mice null for MK2 are viable, whereas mice null for p38 are lethal, suggests that therapeutic inhibition of MK2 may prove less problematical than p38 inhibition [10].
Manager Cullis, the stern disciplinarian who had presided over two title triumphs and an FA Cup win in the space of the previous four campaigns, shuffled his pack vigorously in an attempt to reverse the ominous trend and in January he drafted Thomson into a left-back slot that had proved particularly problematical.
"I have to prove it for myself".
Patience may prove profitable for taxpayers.
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