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Lord Monk Bretton said that the government's reforms were "a Pandora's box that may prove problematical for the future".
Methods involving the analysis of nucleic acids have become widespread in the fields of traditional biology and ecology, however the storage and transport of samples collected in the field to the laboratory in such a manner to allow purification of intact nucleic acids can prove problematical.
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First, setting a benchmark often proves problematical.
Although this method provided a basis for many of the assignments, it also proved problematical for assigning some of the closely positioned methyl resonances such as those arising from Ile329 and Ile375.
In addition, the observation that mice null for MK2 are viable, whereas mice null for p38 are lethal, suggests that therapeutic inhibition of MK2 may prove less problematical than p38 inhibition [10].
Manager Cullis, the stern disciplinarian who had presided over two title triumphs and an FA Cup win in the space of the previous four campaigns, shuffled his pack vigorously in an attempt to reverse the ominous trend and in January he drafted Thomson into a left-back slot that had proved particularly problematical.
It may prove to be problematical.
Ultimately, using atomic protein models refined from low-resolution X-ray data as starting points for further studies such as drug discovery and design may well prove to be problematical or even pointless.
With the Knicks' Amar'e Stoudemire and the Pistons' Tayshaun Prince on the court to offer the crowd a pregame welcome, the microphones they were trying to speak into proved a little problematical, with Prince eventually conceding defeat after some truncated remarks.
Why revisit a problematical show like "St. Louis Woman"?
Beyond this case the presence of interallelic trans-splicing in vertebrates is problematical to demonstrate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com