Co-executive producer Christy Karacas's unique art style also proved laborious for them in that it provided "very clean polished lines" over more organic drawings.
Defining a comprehensive FTD topography in autopsy materials, however, proved laborious and few studies could capture early-stage disease.
To address this problem, HRW might have visited a random sample of Kurdish villages drawn from an existing list of depopulated communities, and if that effort proved too laborious, the group could have used other accepted sampling techniques to select provincial village clusters, weighted by provincial population size.
I used to make up my own which proved a laborious task.
However, these methods have proven to be laborious and sometimes unsatisfactory for serial sectioning.
With this much difficulty with a simple structural model, a more complex and layered computer model, as are the ones currently populating the industry, would prove to be too burdensome and laborious for efficient field interpretation.
It took another seven minutes, however, for Rahane's dismissal to be confirmed as the umpires – in accordance with new International Cricket Council protocol – ordered what proved to be a laborious check to rule out a no-ball.
Although this approach has proved to be too laborious to apply on a large scale in higher metazoans, tagged expression constructs have recently been used to identify the interaction partners of several thousand Drosophila proteins in a tissue-culture cell system (Guruharsha et al., 2011).
Use of such universal molecular adaptors should prove instrumental in a high-throughput screening of bispecific constructs prior to costly and laborious synthesis of lead candidates via recombinant engineering or chemical cross-linking.
"It's more difficult to prove [modification by exposure]." MacCoss tries to address that problem by making affinity reagents that will enrich serum samples for the protein of interest without going through the laborious purification used during the in vitro experiments.
Vaccines work by stimulating the immune system to ward off infections, yet progress on an effective HIV vaccine has proven to be difficult and laborious, according to Dr. Nicholas Hellmann of the Gates Foundation's HIV, TB and reproductive health program.
