The risk of toxicity on those patients of proven high risk would be more acceptable to both clinician and patient.
Patients with histologically proven high risk prostate cancer, but cN0 cM0 stage, were included after providing informed consent.
It can improve the detection of repeated, newly acquired infections in a group with a proven high-risk profile for chlamydia.
We attempted to assess pathology difference by mutation type (missense versus truncating), an issue that has not previously been addressed rigorously because of the limited availability of pathology information for proven high-risk missense mutations.
PUB was defined by the existence of signs of hematemesis, coffee ground vomitus, hematochezia, or melena and proven high-risk ulcers by endoscopy that were defined according to the Forrest classification [ 10].
Only women who can prove a "high risk of violence" (such as having secured a conviction or injunction against their perpetrator) or have been referred for a risk assessment will be eligible for legal aid.
While Spurs' hard-ball stance was eventually vindicated as they managed to receive a satisfactory amount for Modric from Real Madrid a year later, adapting a similar strategy to a fierce South American hell-bent on a move might prove very high risk (the way he forced his acrimonious move from Groningen to Ajax immediately springs to mind).
Alternative drug development may be abandoned for the least interesting vulnerable groups of individuals that prove at higher risk of ADRs for the major drug being developed.
Although uncertainties remain meaning that actual temperatures might be lower even on a worst case scenario, the authors of that paper warned that their research proved "a higher risk that we will experience more severe, not less severe, climate change than is currently forecast".
If we divide the clean-tech startup universe into two categories – 1) Innovative and less capital-intensive startups such as clean-tech software that secure VC funding easily, or 2) Low maturity but potentially disruptive startups that are more capital intensive, yet to be proven and pose high risk – we find that more capital-intensive startups offer the most bang-for-the-buck.
