Sentence examples for protracted schedule from inspiring English sources

Patients with locally advanced tumours or low-lying cancer must benefit from a protracted schedule, which increases down staging and the number of sphincter-preserving surgery.

Our extensive in vitro and in vivo investigations using formal factorial design allowed us to convincingly demonstrate in neuroblastoma pre-clinical models that (a) irinotecan administered on a protracted schedule has remarkable anti-tumour activity; (b) MGMT inhibition enhances the anti-tumour activity of TMZ, confirming MGMT as a relevant pharmacological target.

Regarding the latter, a phase I trial with an over 7-week protracted schedule of TMZ, showed an acceptable tolerance at a daily dose of 75 mg m−2 day−1 (Brock et al, 1998), while increasing two-fold the systemic exposure as compared to the 200 mg m−2 day−1 × 5 per 28-day schedule.

In the present study, profound and persistent AGAT inactivation was noted with two low-dose protracted schedules of temozolomide.

Since studies have not examined AGAT depletion in PBMC and tumour tissues following protracted OBG or temozolomide schedules, it remains to be determined whether the aforementioned pharmacodynamic studies of OBG and temozolomide that utilised brief exposure schedules are relevant to the current study utilising protracted schedules.

Samples collected from 10 patients on protracted schedules of LM were available for analysis.

Indeed, in some studies during long follow-up, better palliative effect was observed in patients applied protracted schedules (Macbeth et al, 1996).

Thus, pulsed schedules with higher doses may be more effective in cells expressing wild-type p53, whereas continued exposure with protracted schedules may be more active in cells expressing mutant p53.

The sustained inactivation of AGAT 7 days after treatment with temozolomide on the protracted schedules evaluated in the present study may have important implications for selecting dose-schedules for further clinical evaluations.

The results of the current study support the assertion of Brock et al (1998) that cumulative 'schedule-dependent' inactivation of AGAT is, in part, responsible for the level of activity noted in preliminary studies of temozolomide administered on protracted schedules.

Cumulative lymphopoenia was observed in 45.4% of our patients, this outcome being comparable to those reported by other authors following other protracted schedules (Brock et al, 1998; Khan et al, 2002; Su et al, 2004; Wick and Weller, 2005).