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Although SOS can interact with both Grb2 and E3b1 (a Rac1 GEF) adaptors simultaneously, very recent studies indicate that the timing of these reactions significantly differ in vivo, the Ras activation occurring in a rapid and transient fashion, while Rac1 activation occurring in a more sustained and protracted manner [ 136].
This is in contrast to the repatriation experience in Syria where rescue operations proceeded "slowly and in a protracted manner".
A twice weekly infusion of SU5416 is safe and able to be delivered in a protracted manner.
By contrast, epiSCs with Klf2 alone produced GFP-positive cells but in a relatively protracted manner on day 6 7, and more robustly on day 9, compared to a highly accelerated rate of reprogramming by Prdm14 and Klf2.
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We have shown that cultured primary trigeminal ganglia neurons and glial cells express COX-2 upon stimulation with IL-1β in a dose and time dependent manner leading to PGE2 synthesis and protracted CGRP release in trigeminal ganglia neurons.
But the (then) EEC responded to this event in a pragmatic manner, enabling a united Germany to become a member without protracted negotiations.
"We don't know whether it will be protracted over a very long period of time, in which case the adjustments will occur in the normal manner without any significance, or whether they'll occur more abruptly," he said.
A protracted silence.
They are also protracted.
Conflicts are becoming more protracted.
What is protracted war?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com