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However, little is known about the consequences of very low dose rate prenatal protracted irradiation over several days on neuron numbers in the offspring brain, and on volumes of the corresponding brain regions.
Thus, according to the model, at least for alpha-particle radiation from inhaled radon daughters, lung cancer induction over long periods of protracted irradiation appears to be dominated by radiation-induced modification of the proliferation kinetics of already-initiated cells rather than by direct radiation-induced initiation (i.e., mutation) of normal cells.
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The protracted irradiations of blood samples also required the maintenance of a tissue culture environment, with control of temperature, humidity, and carbon dioxide content.
Although a long-term, repopulating hematopoietic stem cell is ancestral to all lineages needed to restore normal homeostasis, the dose-response data from the protracted irradiations indicate clearly that the particular lineage that is critical to hematopoietic recovery does not resemble stemlike cells with regard to radiosensitivity and repopulation rates.
In any case, systemic administration of therapeutic radionuclide activities will lead to DNA damage because of the protracted whole-body irradiation.
Most importantly, very low dose rate prenatal protracted γ irradiation did not result in the same morphologic alterations in the offspring brain as previously observed after prenatal single irradiation such as derangement of the laminar structure of pyramidal cells within the hippocampus or malformation of cerebellar lobules.
Pregnant Wistar rats were exposed either to a protracted γ irradiation from embryonic day (E) 13 to E16 (0.7 mGy/min; total cumulative dose approximately 3 Gy) or were sham-irradiated.
In conclusion, a protracted γ-irradiation at a dose rate as low as 0.13cGy.day-1 is able to induce cell responses.
The protracted animal testing of multiple combinations of food and irradiation dose, despite clear evidence of a lack of need, and utility of, such studies provides a close parallel to the current situation with data requirements for GM crops in some jurisdictions.
However, the individuals from this accident were exposed to protracted, fractionated exposures, and the possibility exists that long-term stability may not be observed under these irradiation conditions.
A protracted silence.
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CEO of Professional Science Editing for Scientists @ prosciediting.com