It is known that various stress conditions may produce protracted effects on genome stability, leading to transgenerational changes in genome structure, which are proposed to have been initiated by epigenetic mechanisms [ 31- 37].
Again, the impairment in the s-SLR task cannot be explained by a protracted effect of BDNF ASO on retrieval during the choice phase, because 24 hr after injection of the BDNF ASO, BDNF in the DG was back to control levels.
Further, it is notable that postnatal CAPS was associated with behavioral toxicity that was present several months following the end of exposures, suggesting that developmental CAPS exposures can have protracted effects, thereby underscoring the need for further evaluation of air pollution effects on the CNS and how such exposures may contribute to CNS diseases and disorders.
Diprospane 2 ml contains steroid corresponding to 10 mg of betamethasone with protracted effect and 4 mg of betamethasone with rapid onset.
There is evidence for radiation-induced modulation of effector versus CD4+CD25+ Tregs ratios, and this may have protracted and profound effects on the composition and function of T-cell populations.
On the basis of their mechanism of action (cell killing during DNA replication) and the potential reversibility of the drug effects, protracted therapy with camptothecins is reported to provide optimal antitumour effects.
The demonstration, which students began on the Internet and labeled "Shame," was the first clear sign of popular frustration at the country's protracted political crisis and its worrying effect on financial markets.
As neoadjuvant and adjuvant chemotherapy schedules often consist of multiple treatment cycles over relatively long periods of time, it is important to know what effects protracted drug administration can have on the immune system.
The government's protracted emphasis on personal responsibility deflects attention from these broader determinants of health.
The members of CUPE3903 rejected the offer a week later, starting a protracted strike on October 26.
