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Diprospane 2 ml contains steroid corresponding to 10 mg of betamethasone with protracted effect and 4 mg of betamethasone with rapid onset.
Perhaps the signaling associated with the dampening of electrical activity during SD results in a protracted effect on microglial movement, leading to a long-lasting, maladaptive impact on neuronal excitability evident later.
Similarly to previous analyses, the figure suggests an immediate increase in risk for high temperature, and a more delayed but protracted effect for low temperature.
But, as all patients reported had CYC-refractory disease after a median of three CYC i.v. boli, demonstrating a clear treatment failure of CYC, it does not seem plausible that the distinct treatment response observed after RTX administration is due to a protracted effect of the CYC treatment.
Again, the impairment in the s-SLR task cannot be explained by a protracted effect of BDNF ASO on retrieval during the choice phase, because 24 hr after injection of the BDNF ASO, BDNF in the DG was back to control levels.
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It is known that various stress conditions may produce protracted effects on genome stability, leading to transgenerational changes in genome structure, which are proposed to have been initiated by epigenetic mechanisms [ 31- 37].
Further, it is notable that postnatal CAPS was associated with behavioral toxicity that was present several months following the end of exposures, suggesting that developmental CAPS exposures can have protracted effects, thereby underscoring the need for further evaluation of air pollution effects on the CNS and how such exposures may contribute to CNS diseases and disorders.
In one study, PFOS was shown to impair cerebellar Purkinje cell function in vitro; although this did not involve protracted effects or neurodevelopment, it pointed out the potential for direct actions of perfluorinated chemicals on neuronal cells (Harada et al. 2006).
Indeed, several studies have indicated that the non-additive expression patterns can be established at the initial stages of allopolyploidization but with protracted effects over evolutionary timescales [ 5, 21, 24, 29, 34, 48, 57].
The protracted antidiabetic effects of the most stable compound 14 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo.
The protracted antidiabetic effects of the most stable I-3 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo.
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