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Here, we report a sensitisation model with long term airway allergen challenges which induce typical features of chronic asthma including protracted changes in lung function, airway inflammation, mucus hyperplasia and peribronchial fibrosis.
The observations of protracted changes in neurotransmitter levels coupled with neuronal loss have particular significance, given the critical roles of the nigrostriatal and mesocorticolimbic dopaminergic systems in controlling fine motor behavior and complex cognitive function, respectively (Clark et al. 2004; Crossman 2000; Remy and Samson 2003).
While evidence suggests that adolescent social stressors may result in long term disruption to hippocampal-dependent spatial memory [ 35- 37], we are currently unaware of any research that has tested protracted changes in mPFC DA-dependent spatial working memory as a result of stress in adolescence.
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Why does Favre always seem to be in the middle of some melodrama — whether it was his tearful goodbye to football in his "retirement" news conference or his crazy, protracted change of heart last summer: Am I staying, am I going?
First, there is no empirical reason to think that TMS stimulation of any one area at a frequency of 0.1 Hz would lead to a protracted change in that area's activity which is detectable by fMRI many minutes later.
But protracted set changes and tetchy equipment, including a briefly unattended lamp that sputtered angry white sparks, caused substantial delays.
Microglial whole-cell movement hours following SD could thus be a functional initiating step to the subsequent increased excitability of enlarged expanses of tissue they survey, an effect consistent with the protracted structural changes observed in these cells days after SD [15].
The restrictions on collective bargaining, he claims, are needed to force through the other changes without protracted negotiations.
I loved its resistance to change, its protracted unfolding, its mantric sense of perpetual return.
In addition to the protracted famine conditions, climate change is already menacing Haitian farmers.
There is very little belief that the world community is prepared for the heavy lifting that a comprehensive settlement would entail; however, it is unlikely that more promises or protracted negotiations, without real change, could head off the escalating violence.
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