Sentence examples for prototype region from inspiring English sources

The A/H1N1 and A/H3N2 subtypes effectively hybridized to the same prototype M sequence (derived from the A/NWS/33 H1N1 strain), confirming that M genes are conserved among different H/N subtypes of influenza A to allow the universal identification of influenza A subtypes with a single tiled prototype region.

Thus it is possible to use this model for evaluating the performance of database sequences as potential prototype regions.

The described design method could be applied to any group of sequences and a minimum set of prototype regions would be determined.

This indicates that a redesign of the HEV prototype regions is needed where selection of a minimal set of prototype regions would be based on all available 5'UTR sequence data (complete and partial) and not a subset of genome sequences.

Of the 34 HRV strains, 18 matched the selected prototype 5' UTR sequences on the RPM-Flu v.30/31 chips and showed strong hybridization signals to their corresponding prototype regions generating at least 86% base call rates.

Due to the sequence homology, it is not surprising to find a noticeable and sometimes significant amount of hybridization (20 – 80%) leading to base calls on prototype regions other than the correspondent prototype for most samples.

With resequencing arrays such as RPM version 1, multiple contiguous sequences (range 100 bp to 2 kb) containing both conserved and unique target genes from each species or subtype can be selected as prototype regions, and every nucleotide from the hybridized target regions can be potentially read as an independent data point using resequencing algorithms (5 ).

Due to the great genetic diversity of HRV and HEV, in order to ensure that designed probes (referred to as probe sequences) generated from selected database sequences (referred to as prototype regions) would detect and discriminate all serotypes of HRV and HEV, a predictive model was used to assist the microarray design [ 17].

The prototype regions targeting influenza viruses were composed of partial sequences from HA genes of influenza A virus subtypes (H1, H3, and H5) and influenza B virus, NA genes of influenza A virus subtypes (N1 and N2) and influenza B virus, and the M genes of influenza A virus (full-length M1 and partial M2) and influenza B virus (Table 1).

RPM version 1 can differentiate a broad number of variants based on a single-tiled "prototype" probe region without relying on predetermined hybridization patterns (9 ).

An adventurous family in each town will offer their typical suburban front lawn as a working prototype for the region.