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With the EAL-domain PDE YciR as a prototype, our study introduces the concept of trigger enzymes into c-di-GMP signalling.
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A single-centre study of 52 cases using the Aixplorer system, which was developed from the RUBI SWE prototype used in our study, compared two observers who independently measured the mean SWE from two previously acquired pairs of images and found an interobserver ICC of 0.99 [ 18].
Two major prototypes were used in our study, based on previous literature observations.
In our study, the prototype filter of the FBMC-based CR is designed according to the PHYDYAS model [38], with K = 4.
Although there is some undesired background uncoupling induced by MitoDNP-SUM, thus making it a prototype rather than drug candidate, our study represents the first example of a mitochondria-targeted prodrug that releases its payload in direct response to mitochondria-generated ROS.
In our study, the third prototype of adult attachment style (secure) did not exhibit any unique correlate for neural responses to the perceived social meaning of facial expressions, but mirrored the pattern found for AVS and AXS, respectively.
Our study provides a prototype that could be useful for other studies aiming to disentangle RA complexity.
Our study also provides a prototype for how empirical scans for ancient selection can be carried out once many genomes are sequenced.
Therefore, the agile development approach was followed in our study to iteratively design prototypes and elicit feedback from the end-users.
Our prototype case study suggests that once we have implemented the whole MAPE-K chain for a small number of key parameters (e.g., the number of messages in the queue, message queuing time, and the execution times from workers), the introduction of additional monitoring parameters becomes a trivial task, and does not necessarily bring scientific contribution.
Our experiences are based on our ongoing tight collaboration with a local hospice as well as our studies of prototype technology infrastructures we have developed in our laboratories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com