In this context, mixed cryoglobulinemia syndrome (MCs) represents the prototype of virus-related autoimmune-lymphoproliferative diseases.
Until the 1960ies, the influenza virus was kind of a prototype of a virus and was subject of intense fundamental research on the area of virology [ 10].
The prototype of these viruses is the avian leukosis virus RSA (also known as Rous sarcoma virus), which contains three genes (gag-pro, pol, and env) between flanking LTRs.
With the use of a technique known as reverse genetics, a prototype of influenza virus (H5N1) has been produced for the development of an inactivated subvirion vaccine.
The nucleotide sequence and phylogenetic analysis also showed that Solovey and Primorye sequences were most closely related to AMR and H8205 sequences from patients in Russia and China, but were clearly distinguishable from the prototype of Hantaan virus.
Borna disease (BD) is a severe immunopathologic disorder of the central nervous system induced by infection with Borna disease virus (BDV), the prototype of a new virus family, Bornaviridae, within the order Mononegavirales.
On the basis of the high percentage sequence identity for the complete F proteins of the prototype viruses of the four lineages, sequences for the complete F proteins of all 84 samples would probably demonstrate similar low variability.
The prototypes of these viruses are A/Anhui/1/2013 and A/Shanghai/1/2013.
QM-polarized ligand docking and molecular dynamics simulations of selected active compounds in the active site of prototype foamy virus intasome gave important insights into the chemical and structural basis involved in the molecular recognition process.
Norwalk virus is the prototype of the genus Norwalk-like virus (NLV) in the Caliciviridae family, which includes a large number of genetically related strains that together represent the most important cause of gastroenteritis outbreaks worldwide (1, 2 ).
The HA, NA, nucleoprotein (NP), matrix (M), and polymerase PB2 genes of the viruses from Bangladesh originated from the prototype G1 virus A/Qa/HK/G1/97 (H9N2).
