Sentence examples for prototype of compound from inspiring English sources
For the controls, 75.4%–80.8% of the cells were viable in the biofilm treated with vancomycin (128 µg/mL), and 69.8% of the cells were viable in the biofilm treated with the prototype of Compound 2. Using 0.1% dimethyl sulfoxide (DMSO) as a negative control, 92.4% of the cells were viable in the biofilms.
High pressure computational work once again provided good correlation between the experimentally observed compressibilty of aurophilic interactions and that observed in computational simulation on the prototype system of compound 1 (see the Supporting Information).
The prototype of these compounds had been described by Holý in 2002.
The present investigation expands on the study of structure activity relationships of prototype compound 2 by constraining the molecule into a macrocyclic structure with the aim of improving its G-quadruplex binding activity and selectivity.
The mechanisms of tumor promotion by several representative prototypes of these compounds were studied in rat liver in vivo.
The prototype compounds of these new series showed nanomolar inhibition of the kinase.
Edelfosine (1- O-octadecyl-2 O-methyl rac-glycero-3-phosphocholine) is the prototype compound of a family of promising synthetic antitumor drugs collectively known as alkyl-lysophospholipid analogs or antitumor ether lipids.
The LAB027 compound that associates a quinone core along with two tellurium atoms can thus be considered as the prototype of pro-oxidative tellurium compounds.
Further optimization of this prototype compound may lead to the discovery of valuable pharmacological tools for the study of caspase-2 mediated cell death, particularly as it relates to HD.
To address these questions, we first extensively examined the assembly and folding of compound 1, as a prototype of the series.
Thus the present data shows the potential of these compounds as prototype of protease inhibitors on drug design studies for developing new antichagasic compounds.
