Sentence examples for prototype compounds with from inspiring English sources

Of note, widely variable responses to opioids have been reported between rats and mice, and species differences have gained relevance for predictive validity since prototype compounds with demonstrated analgesic efficacy in rodents have often failed in humans (Mogil, 2009).

Evaluation of the fidelity of the bioreactor and new organotypic systems could be verified by assessing metabolite profiles with specific test compounds using prototype compounds whose metabolism had already been well-studied in vivo.

The crystalline structures of selected prototype compounds have been solved.

Doxorubicin and daunorubicin together can be thought of as prototype compounds for the anthracyclines.

Rotenoids are isoflavonoids derivatives, with a prototype compound named rotenone, which is a mitochondrial inhibitor.

The CC50 values of all the derivatives were therefore greater than 200 μM higher than that of the parent prototype compound (50 μM Cells treated with 0.1 % DMSO showed no cytotoxicity (Table  1).

Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.

Compared to the prototype compound 2, they had less cytotoxicity for Vero cells and less hemolytic activity for human erythrocytes.

Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H -ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities.

Evaluation of the fidelity of the bioreactor and new organotypic systems could be verified by assessing metabolite profiles with prototype test compounds, i.e. those whose metabolism has already been well-documented in vivo or through other systematic approaches (Choi et al., 2012).

It has served as a prototype for chemical optimization and has fostered the discovery of compounds with better drug properties and efficacy.