Sentence examples for prototype compounds in from inspiring English sources

Prototype compounds in these series were found to produce significant increases in an iberiotoxin (IbTx -sensitive hyperpolarIbTx -sensitivethyperpolarizingthat these relatively modest strucurrentmodificathussuggesting in a swithatin theseechanism of action of these smooth muscle relativelyfromodest channel openerstructuralators of the large-conductance Ca2+-activated potassiumodificationsCa).

The prototype compounds were tested in a model system consisting of large unilamellar vesicles exposed to a copper-dependent radical generating system.

Of note, widely variable responses to opioids have been reported between rats and mice, and species differences have gained relevance for predictive validity since prototype compounds with demonstrated analgesic efficacy in rodents have often failed in humans (Mogil, 2009).

Evaluation of the fidelity of the bioreactor and new organotypic systems could be verified by assessing metabolite profiles with specific test compounds using prototype compounds whose metabolism had already been well-studied in vivo.

The crystalline structures of selected prototype compounds have been solved.

Doxorubicin and daunorubicin together can be thought of as prototype compounds for the anthracyclines.

Also in a global context, modern pharmacopoeia still contain in the order of 25% drugs derived from plants and many others which are synthetic analogues built on prototype compounds isolated from plants.

To assess the impact of gain-of-function β-catenin on ABCB1 and drug resistance and potential response to therapy in colon cancer cells we screened a mechanistically diverse library of anticancer drugs and prototype compounds.