Sentence examples for prototype compounds from inspiring English sources
The crystalline structures of selected prototype compounds have been solved.
The prototype compounds of these new series showed nanomolar inhibition of the kinase.
The prototype compounds were tested in a model system consisting of large unilamellar vesicles exposed to a copper-dependent radical generating system.
Biological testing of the prototype compounds showed that they represent new peptidomimetic hits; importantly, the modular nature of the scaffold provides an interesting starting point for future ligand optimization.
The use of nanoparticle parenteral drug delivery systems for oral, IV injection and IV infusion of tool compounds to reach desired exposures allows researchers to obtain reliable and critical data for early decision making early in the discovery process without large investment by utilizing less-than-ideal, prototype compounds for target validation.
Prototype compounds in these series were found to produce significant increases in an iberiotoxin (IbTx -sensitive hyperpolarIbTx -sensitivethyperpolarizingthat these relatively modest strucurrentmodificathussuggesting in a swithatin theseechanism of action of these smooth muscle relativelyfromodest channel openerstructuralators of the large-conductance Ca2+-activated potassiumodificationsCa).
The anticonvulsant effect of compound 11l was blocked by flumazenil, suggesting the involvement of benzodiazepine (BZD) receptors in the anticonvulsant activity of prototype compound 11l.
Compared to its prototype compound 18, deuterated analogues 19 and 21 showed obviously higher plasma concentrations and better PK parameters after oral administration in mice.
A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.
Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
A prototype Compound Parabolic Concentrating (CPC) solar energy collector for a sorption refrigerator has been designed, built and tested in laboratory at Warwick University.
