Sentence examples similar to prototype compound of from inspiring English sources

IQ-FdUrd is potentially a prototype compound for new class of radiation-activated antitumor prodrugs that are useful for radiation treatment of hypoxic tumors.

The prototype compounds of these new series showed nanomolar inhibition of the kinase.

Doxorubicin and daunorubicin together can be thought of as prototype compounds for the anthracyclines.

The present investigation expands on the study of structure activity relationships of prototype compound 2 by constraining the molecule into a macrocyclic structure with the aim of improving its G-quadruplex binding activity and selectivity.

The anticonvulsant effect of compound 11l was blocked by flumazenil, suggesting the involvement of benzodiazepine (BZD) receptors in the anticonvulsant activity of prototype compound 11l.

Flow cytometric analyses revealed that the prototype compound 3e can prevent the proliferation of HepG2 cells by blockade of the cell cycle at the G2 phase and induction of apoptosis.

The high potency and specificity of this drug makes it a prototype compound and a very useful tool for studying the effects of HDACIs.

In summary, the bactericidal and antibiofilm activities of the six newly designed derivatives of YycG inhibitors are improved compared to prototype compound 2.

The pan-caspase inhibitor z-VAD.fmk is a prototype compound that has been used extensively in vitro and in animal models for proof-of-concept studies.

Previously, we reported that a prototype compound (D1, a small molecule representing a proelectrophilic, para-hydroquinone species) exhibited neuroprotective action by activating both of these pathways.

Rotenoids are isoflavonoids derivatives, with a prototype compound named rotenone, which is a mitochondrial inhibitor.