Sentence examples for prototype cell line from inspiring English sources
Based on its relatively high sensitivity to drug-induced ROS generation and apoptosis, NB4 was chosen as a prototype cell line for cellular and molecular assessments prior to detailed transcriptome analysis.
The clustering shown in Figure 6 allows to propose, using two independent classifiers, prototype cell lines of papillary/luminal tumor phenotypes (i.e. RT4, UM-UC-7), and Basal-like tumors (well represented by several cell lines).
Three NCI prototype cancer cell lines, PC3 prostate cancer, MCF-7 breast cancer and NCI-H460 NSCL, were used in our initial screen.
The prototype of a human CML cell line is K562, derived from a pleural effusion of a patient suffering from CML in terminal blast crisis [ 14].
The murine L929 fibrosarcoma cell line has been the prototype cellular model system for identifying pathways involved in necroptosis.
The RASF cell line was determined as a prototype of activated synovial fibroblasts.
Moreover, the antiproliferative efficacy of the most promising nanoparticulate prototype was assessed by in vitro cytotoxicity assay toward a human prostate cancer cell line (PC3).
This cell line was chosen for the xenograft studies because it is a prototype of molecular apocrine subtype and has been previously employed for in vivo studies of the AR-ERK feedback loop [ 4, 5, 9, 12].
In cell culture experiments, the treatment with α-naphthoflavone (αNF), a prototype SAhRM, exerted cell line-specific effects: in ERα-negative human UACC-3199 sporadic breast cancer cell line, it rescued BRCA-1 and ERα expression, while inducing CYP1A1; in ERα-positive MCF-7 breast cancer cells, αNF antagonized E2-dependent stimulation of BRCA-1 without affecting ERα expression.
Prototype human adenoviruses were cultivated in 293 or A549 cells, and dengue and Japanese encephalitis viruses were grown using the mosquito cell line C6/36.
