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Delineation of these relationships by methods such as the one developed here, which is general and can be applied to other types of well defined dynamics, will greatly advance our understanding of the design principles of prototype biological systems.
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We demonstrate our methodology on a prototype biological system of perfect adaptation dynamics, namely the chemotaxis model for Escherichia coli.
The mission of the DAMP (Design, Automation, Manufacturing, and Prototyping) Laboratory is to develop novel biological systems using formal representations of protocols and experiments for the specify-design-build-test cycle.
A systematic approach based on enrichment statistical tests has been developed to elucidate the relationships between model parameters and the roles they play in affecting system dynamics of a prototype biological network.
In other words, the Jamboree, an undergraduate contest to design new biological systems, is itself a method for prototyping the ways in which life will be designed in the future.
This prototype platform can be a springboard for advanced and broad-scope modeling of complex biological systems by integrating other "omics" data or C- metabolic flux analysis results.
Once a prototype reaction is selected, an in-depth mechanistic analysis is essential to guide the requisite adaptations for use in biological systems and to anticipate potential pitfalls.
Hence, people are intricate biological systems.
Biological systems are variable.
Biological systems are complex.
So, many biological systems work like this.
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