With these ligands, up to 94% ee was obtained for the alkylation of arylaldehyde with diethylzinc.
EMT-type zeolite, EMC-2, for example is an extremely effective industrial catalyst for the alkylation of isobutane with 2-butene (Stocker et al., 1996 ▸; Rosenbach & Mota, 2005 ▸).
The sesquiterpene parthenolide has proven particularly useful for promoting the alkylation of Cys38 in the RelA subunit of NF-κB, thereby preventing DNA binding [ 137, 272].
Alternatively for compounds 61– 70, the alkylation of the 3-iodoindazole was completed first and the Suzuki reaction, to add the aryl substituent, was employed as a final step.
Furthermore, a novel method for the direct investigation of the alkylation of DNA by alkylating agents using ESI FTICR MS was developed, which can be used to estimate relative alkylation efficiencies as well as the sites of alkylation of the DNA by different alkylating agents.
Plates were incubated at 37°C, 5% CO2 for 15 min to allow the alkylation of free thiol.
The alkylation of sulfhydryl groups was performed by additions of dithiothreitol for 30 min at 55 °C followed by the addition of iodoacetamide for 20 min at room temperature.
Several works investigated the alkylation of thiophenic sulfur catalysts.
Through the alkylation of thiophene and its derivatives with olefins followed by distillation, alkylation desulfurization is an alternative technology in the case of gasoline for its mild operation conditions and low loss of octane number.
As the reaction conditions of alkylation reaction are mild, benzenesulfonic acid melts to catalyze the alkylation of thiophenic sulfur in the gasoline during the reaction process.
