Many of the variables we found to be important when assessing the trial (eg, date of trial protocol, date of unblinding, date of participant enrolment) are simply not captured in the risk of bias tool when used in a routine way or to review publications.
The phrase "women and children first" did not appear until a few years after the Birkenhead went down, but the protocol dates to its evacuation.
After the protocol column, we create columns to capture the attributes of the protocol including the name of the person who performed the protocol, the date when the protocol was applied, and the values of each parameter in the protocol.
The plan released on Tuesday included some of the most detailed protocols to date.
The most rigorously discussed reactive wireless (on-demand) routing protocols to date have been Dynamic Source Routing (DSR), Ad hoc On-Demand Distance Vector Routing (AODV) and Temporally Ordered Routing Algorithm (TORA) [18 20].
In addition, this study is based solely on Stratus OCT data, which is still the most commonly used OCT in research protocols to date; however, it will be probably replaced soon by Fourier domain OCT (FD-OCT) devices.
If we need to amend this protocol, the date, rationale and a description of each protocol change will be reported.
