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All experimental protocols conducted in this study were approved by the Florida State University Animal Care and Use Committee.
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The animal breeding protocol as well as the experiments conducted in this study are approved by the Institutional Animal Care and Use Committee (IACUC) of the National University of Singapore (IACUC Protocol 755/05 and 828/05).
Protocols approved by the Khon Kaen University Animal Ethics Committee were used for all animal research conducted in this study.
Two experimental protocols were conducted during this study.
All three studies followed the same study protocol and were conducted in the same study clinic (Singapore Eye Research Institute, Singapore).
While the main protocol was conducted in several different hospitals, this study was a substudy supplemental to the main study that was only conducted in one of the hospitals.
The Investigation file is a reference for the different assays and protocols that have been conducted in a single study.
AD developed the study protocol, conducted the initial search for studies, assisted in study selection and data extraction, analyzed the data, and wrote and revised the manuscript.
All study protocols were conducted in accordance with the Declaration of Helsinki [21] and were approved by the ethics committees of Tokyo Dental College (approval #416) and Fukuoka Dental College (approval #213).
Study protocols were conducted in accordance with the principles of the Declaration of Helsinki.
The study protocols were conducted in accordance with the tenets of the Declaration of Helsinki and approved by the Medical Ethics Committee of Zhujiang Hospital of Southern Medical University and Mingjing Diabetes Hospital.
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