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We followed the protocol revised by Wolfer and Lipp [ 76].
GG and GAB designed the study, wrote the study protocol revised the manuscript critically.
FF designed the study protocol, revised all patients' files and rough data, interpreted the results, and wrote the paper.
JAS drafted the initial study protocol, revised protocol, prepared IRB application, reviewed the data abstraction and data analyses, prepared the first draft of the manuscript, and revised the manuscript.
However, in order to minimise inappropriate usage and prior to phase 3, we updated our protocol (revised by our blood bank haematologist and then approved at the transfusion medicine committee) for PCC prescription to include a complete list of appropriate indications, the correct dosing regimen and the important contraindications [ 31].
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AMT participated in the acquisition of data (developed preliminary MR imaging assessment protocol), revising the article, and provided final approval of the version submitted.
JMAH: Provided overall supervision and coordinated all experimental activities, initially approved the experimental protocols, revised manuscript, carried out experiments.
DH drafted the protocol and the protocol was revised critically by KR and LB.
Comparison between the three groups (no protocol, CPOE protocol and the revised CPOE protocol) was carried out using the Chi-square test for categorical variables, whereas the independent student's t-test was used for continuous variables.
In addition, all arms of the study, the no protocol, the CPOE protocol and the revised CPOE protocol, were considered acceptable clinical practices.
Two hundred seventy nine patients were included (no protocol = 91, CPOE protocol = 97, revised CPOE protocol = 91).
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