Exact(7)
A thorough examination of the review text revealed that only 4(6%) of the 64 reviews with deviations from the protocol outcome specifications described the reason for the changes in the review.
An upgrade occurred if a secondary protocol outcome was promoted to a review primary outcome and a downgrade occurred if a protocol primary outcome was demoted to a review secondary outcome.
If a protocol outcome was included or upgraded to a review primary outcome, and the meta-analysis for that outcome gave a significant pooled effect estimate (p<0.05), then this would increase our suspicion of bias since the reason for the inclusion/upgrade could have been influenced by the significance of the result.
Several variant callers were compared to improve the protocol outcome.
OH - refining of protocol, outcome assessment tools and contribution to protocol publication, IB - refining of protocol, outcome assessment tools, and contribution to protocol publication.
TF participated in the development of the protocol, outcome assessment, data acquisition and analysis and writing of the manuscript.
Similar(53)
*Sustainability Survey: PEC co-chair 18 months Measures perceived benefits of the MATICCE intervention, staff engagement in the process, leadership buy-in and organizational structures in place to support continued sustainment of protocol outcomes and processes; collected at 6 months post-intervention.
Even in the absence of a protocol, outcomes listed in the methods section of the published report can be compared with those for which results are presented.
Sensitivity analysis suggests that results are robust to a per-protocol outcome analysis and are sensitive to the cost of blood transfusions.
Though we can readily show that none of the reportedly "positive" four non-protocol outcome variables stands up to scrutiny, the primary mandate of the RIAT enterprise is to reaffirm essential practices in randomised controlled trials, so we did not include these variables in our efficacy analysis.
Treatment protocols, outcome, and exposure measurements.
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