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Using an experimental model to clarify the pathways of nephropathy evolution in a protocol of conversion from CsA to SRL, J. Sereno et al. demonstrated how conversion to SRL prevented CsA-induced renal damage evolution.
The current study intended to clarify the pathways of nephropathy evolution in a protocol of conversion from CsA to SRL in the rat, focusing on serum, urine, and renal (gene and protein) tissue samples, as well as to elucidate the involvement of several emergent biomarkers of renal damage which are putative candidates to act as players in the evolution from renal dysfunction to nephrotoxicity.
The current study was intended to clarify the pathways of nephropathy evolution in a protocol of conversion from CsA to SRL in the rat, focusing on serum, urine, and renal (gene and protein) tissue samples, as well as to elucidate the involvement of several emergent biomarkers of renal damage which are putative candidates to act as players in the evolution from renal dysfunction to nephrotoxicity.
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Protocols of conversion from cyclosporin A (CsA) to sirolimus (SRL) have been widely used in immunotherapy after transplantation to prevent CsA-induced nephropathy, but the molecular mechanisms underlying these protocols remain nuclear.
With nephrotoxicity remaining a major contributing factor to late allograft damage, it is crucial to understand the impact on the kidney tissue of protocols of conversion from CsA to SRL and identify early biomarkers in order to improve the therapeutic strategies after transplantation, thus extending long-term graft survival by reducing cardiorenal mortality.
The objectives of this prospective observational study were to assess the effectiveness and safety of a standardized protocol for conversion from intravenous to subcutaneous insulin therapy in patients with acute coronary syndrome (ACS) during the transfer from the intensive cardiac care unit (ICCU) to the general ward; and identify predictive factors of transition outcome.
assess the effectiveness and safety of a standardized protocol for conversion from intravenous to subcutaneous insulin therapy in patients with acute coronary syndrome (ACS) during the transfer from the intensive cardiac care unit (ICCU) to the general ward; and identify predictive factors of transition outcome.
ALP activity was measured with standard protocols for conversion of p-nitrophenyl phosphate (p-NPP) to p-nitrophenol (p-NP) (Sigma Kit 104, Vienna, Austria).
Table 1 reports the DDD protocol for conversion.
GPRS interface server is in charge of the protocol conversion of transport layer and application layer between GPRS and CTC/TDCS systems as well as IP address transformation of two systems.
Figure 11 Optimal throughput for the TSR protocol for different values of conversion noise variance.({sigma _{c}^{2}}) and ({sigma _{a}^{2}}=-80) dBm (fixed).
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