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A second limitation of our study results from the exercise protocol; exercised animals were included to assess the effects of chronic damage in the DMD models, yet because exercise was induced before imaging scans, acute effects of exercise might confound our imaging findings.
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The DipEx patients tolerated the protocol, exercising 4.2 ± 1.3 minutes on the treadmill (Bruce protocol).
Furthermore, Kubo et al. [37,42] presented the data of one intervention in two articles, as indicated by the same number of participants and anthropometrics, training protocol, and results of tendon stiffness and CSA (LC protocol exercise group in [42]).
V o2max was determined using a maximal Bruce treadmill protocol exercise test.
Training included information about study procedures and protocol, exercise delivery, progression and monitoring.
Patients performed a symptom-limited Bruce protocol exercise test with assessment of TWA by the spectral method.
The subjects will receive some of the protocol exercises (appendix 2) to augment the joint mobilisations, which will collectively make up the MPT intervention.
According to the protocol, exercise was increased incrementally until the V ˙ O2 reached a plateau and was not increase further in spite of increased effort.
To set up a high quality protocol, exercises are taken from papers investigating exercises for shoulder rehabilitation [ 62- 79], and exercises specifically addressing deficits in strength, mobility, or coordination revealed in patients with SIS [ 19, 23- 25, 31, 80, 81].
This study clearly demonstrated that ivabradine treatment in patients with stable angina receiving the β-blocker atenolol resulted in a significant long-term improvement in total exercise duration in standardized Bruce protocol exercise testing.
Adverse effects or health problems attributable to the testing protocol or interventions exercise protocol will be documented and reported.
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