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The inferred germline antibody already harbors potential binding pockets for a glycan and a short protein segment.
These techniques have recently been used to determine the average time needed for two residues in a peptide or protein segment to form a contact.
For cardioviruses and the related aphthoviruses, the first protein segment translated from the plus-strand RNA genome is the Leader protein.
Although the exact role of the loop remains to be further explored, it is now clear that this protein segment is specific to the processing of 8-oxoG.
Smithies suggested that the strong hydrophobic shield produced by the phenyl groups of the phenytoin molecule protects the hydrogen bonds, formed by the imidic part of the hydantoin ring and a β-bend protein segment from water extrusion [7].
Here, we obtained vaults by engineering at the N terminus of rat major vault protein (MVP) an HIV-1 Gag protein segment and determined their near-atomic resolution (∼4.8 Å) structures in a solution/non-crystalline environment.
Affinity maturation then leads to divergent evolutionary branches that either focus on a single glycan and protein segment (e.g., Ab PGT124) or engage multiple glycans (e.g., Abs PGT121 123).
These results indicate that the molecular determinants responsible for rundown kinetics and for receptor desensitization are not associated with the same protein segment.
Similar(3)
A genetic algorithm is employed to find the superimposition of protein segments that maximizes their similarity.
The methodology is more generally applicable to the production of intrinsically disordered protein segments.
These measurements also confirm a high level of flexibility in the protein segments exhibiting variable conformations in the crystal structures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com