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Thus, a protein sector can be associated with diverse functions as previously reported [ 6].
The approach of protein sector analysis may not be applied to disease genes with few homologous sequences in the database.
Our results from the protein sector analysis of SMS suggest a possible link between groups of co-evolving residues and disease severity.
Protein sector analysis may also provide useful information for understanding the effect of mutations at spatially distant positions on disease phenotypes.
The novelty of the work is mainly on the protein sector analysis based on residue co-evolution for sorting mutations and then relating them to diseases.
The protein sector analysis of our test cases revealed a possible link between different disease phenotypes and the locations of the mutations within groups of co-evolving residues.
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You've seen advances in other animal protein sectors, they've been optimized, whereas with insects were just getting going in the process".
Careful statistical analyses of co-evolving amino acid sites that can reliably detect co-evolving protein sectors [60] and other metrics of evolutionary constraints [61] could be computed in high-throughput for entire proteomes and incorporated into the ePlant Sequence Explorer and Protein Structure Model Explorer.
Halabi and colleagues [ 43] showed that statistical protein sectors correspond to functional sectors.
This finding supports a degree of differentiation between protein sectors and domains.
The identification of protein sectors was accomplished using the methodology previously described [ 6, 11].
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