Sentence examples for protein pinch from inspiring English sources

In platelets, ILK contributes to inside-out integrin activation [27], and participates in a ternary complex – together with particularly interesting new Cys-His protein (PINCH) and parvin – that functions as a signaling platform for integrins [28].

At the N terminus of this molecule 4 ankyrin repeats bind to both ILK-associated phosphatase (ILKAP) and particularly interesting new cystine-histidine protein (PINCH).

Overexpressed thymosin β4 (Tβ4) induces EMT in colorectal carcinoma by increasing integrin-linked kinase (ILK) complex formation with particularly interesting new cysteine-histidine rich protein (PINCH) [ 32].

The adaptor protein PINCH is overexpressed in the stroma of several types of cancer, and is an independent prognostic marker in colorectal cancer.

The physical tension generated during epithelial remodeling induces an upregulation of dgrasp mRNA and is dependent upon integrins and the subsequent recruitment and/or activation of RhoA and the LIM protein PINCH (Schotman et al., 2009).

Particularly interesting new cysteine-histidine rich protein (PINCH), as a newly discovered protein of LIM family members, may play a role in signal transduction of integrin and growth factor, and involved in the incidence and development of tumors.

For proper FA signaling, FA assembly has to be accomplished by a diverse set of membrane and cytoplasmic proteins including cell adhesion molecules, growth factor receptors as well as adapter and structural proteins such as actin, Rho GTPases and the Particularly Interesting New Cysteine-Histidine-rich proteins (PINCH) 1 and 2 [12], [12].

ILK also binds to the adapter proteins Parvin, Pinch, and Paxillin (Pax), thereby providing an integrin signaling platform (Legate et al., 2006).

While PINCH protein is an adapter protein and localizes to the cytoplasma and cell-matrix adherens junctions in cell lines, especially in peritumoral stromal cells as a marker for tumor-associated stromal cells.

LIM-domain containing proteins (which include paxillin and pinch proteins) can be found in all groups (supplementary table S6, Supplementary Material online).

Dynamin, in conjunction with other proteins, then pinches the neck of the vesicle to form a new subcellular compartment (Table 1), after which the nascent vesicle loses its clathrin coating.