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The hybrid protein, integrated homogeneously with collagen fibrillar networks, preserved structural stability over a month.
Depletion of ER Ca2+ stores is sensed by the stromal interaction molecule 1 (STIM1) protein integrated in ER membrane, which in turn induces the opening of ORAI1 calcium release-operated calcium channels (CRAC) located in plasma membrane and Ca2+ influx [ 58, 59].
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The protein integrates into the bilayer during the first 5 ns in a repeatable process.
The TIR1 (transport inhibitor response 1) gene encodes an F-box protein integrating the SCF complex that mediates Aux/IAA degradation [ 70].
On the other hand, the highest scored candidate protein integrating the band n° 8 was the IgG Fc binding protein (IgGFcBP), a secreted protein present in the colon mucus.
Van Lehn et al. have now used computer modeling to simulate how a bacterial protein called EmrE (which is a dual-topology protein) integrates into the membrane via the translocon.
The protein integrates diverse signals associated with DNA damage and uncontrolled proliferation to govern adaptive downstream responses such as increased DNA repair, arrested cell cycle, and apoptosis (Vousden and Lane, 2007).
The disease is caused by several mutations in proteins integrated in the Usher protein network.
The presence of numerous cellular proteins integrated into mammalian expressed VLP may raise concerns of autoimmunity.
The proteomic analysis identified several differentially regulated proteins integrated in a common network linked to changes in cell morphology.
Comparable to full-length GDAP1, the chimeric proteins integrated also efficiently (25% ±3% and co-sedimented with porin.
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