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Furthermore, AEG-1 functioned as a critical protein in the regulation of EMT by directly targeting multiple positive regulators of the Wnt/β-catenin signaling cascade, including GSK-3β and CKIδ.
Berger, K. et al. Mitochondrial ATP synthase - a possible target protein in the regulation of energy metabolism in vitro and in vivo.
Using this new compound, we delivered a specific siRNA designed to knockdown cofilin-1, a key protein in the regulation of cellular cytoskeleton, to human prostate cancer (PCa) cells.
Yet, emerging data has identified a potential role for this protein in the regulation of cell survival and for this reason we found it worthy of further study.
This indicates a subtle involvement of the PII protein in the regulation of some steps of primary C and N metabolism in plants [32].
The use of mouse models of CYLD deficiency has implicated the protein in the regulation of multiple physiological processes including T cell development and activation, B cell homeostasis and function, osteoclastogenesis and spermatogenesis (Reviewed in [2]).
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Argonaute, one of the important proteins in the regulation of miRNA biogenesis, is a target of miR403 whereas miR408 regulates a copper ion binding protein.
Yamamoto, M. & Takeda, K. Role of nuclear IκB proteins in the regulation of host immune responses.
Cardiac-derived autocrine-paracrine secreted proteins in the regulation of cardiac signaling pathways.
Biochemical studies of sea urchin EMAP and vertebrate EMLs implicate these proteins in the regulation of microtubule stability.
Hasan, A., Cotobal, C., Duncan, C. D. & Mata, J. Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
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