Sentence examples for protein in the pathogenesis of from inspiring English sources

These combined data suggest that the nature of most ENG mutations is to create a null (nonfunctional) allele, and that there is no requirement for the synthesis of a truncated endoglin protein in the pathogenesis of HHT.

Indeed, inhibition of LSD1 activity and or expression has been shown to attenuate estrogen signaling in breast cancer cells in vitro, implicating this protein in the pathogenesis of cancer.

However, the role of this protein in the pathogenesis of histoplasmosis has not been elucidated.

However, the role of this protein in the pathogenesis of H5N1 infection is unknown.

Recent data suggest potential roles for this protein in the pathogenesis of rheumatoid arthritis, being highly expressed in rheumatoid synovium.

Similarly, exogenous delivery of Hsp70 increased lifespan in G93A mice, indicating the importance of this protein in the pathogenesis of ALS [76].

Recent studies have revealed the involvement of calcification inhibitory proteins in the pathogenesis of pseudoxanthoma elasticum (PXE).

We also characterize the ECM alteration in the fibrotic response under diverse cardiac pathological conditions and depict the role of matricellular proteins in the pathogenesis of cardiac fibrosis.

The administration of naked nucleic acids into animals is increasingly being used as a research tool to elucidate mechanisms of gene expression and the role of genes and their cognate proteins in the pathogenesis of disease in animal models (Herweijer and Wolff, 2003; Hodges and Scheule, 2003).

The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown.

We compared intratracheal Pseudomonas infection in wild type and caveolin-deficient mice to investigate the role of caveolin proteins in the pathogenesis of Pseudomonas pneumonia.