LOXL4 encodes a lysyl oxidase-like protein implicated in collagen remodelling and metastasis formation in cancer.
Poor sleep, more common in old age, is linked to the protein implicated in Alzheimer's disease.
Other probes include one that detects a protein implicated in the bone changes associated with cancer and arthritis.
Akt1 is a multi-functional protein, implicated in multiple human solid tumors.
Avidia scientists have shown that an avimer designed to inhibit human interleukin-6 (IL-6) – a protein implicated in rheumatoid arthritis and Crohn's disease – works in mice.
Beloglazova, N. et al. Nuclease activity of the human SAMHD1 protein implicated in the Aicardi-Goutieres syndrome and HIV-1 restriction.
I will focus on two model systems, the mussel foot protein implicated in underwater adhesion of mussels to rocks, and the Tau peptide implicated in Alzheimers Disease.
We used this approach to reveal cellular pathways responding to the toxicity of alpha-synuclein, a protein implicated in several neurodegenerative disorders including Parkinson's disease.
Akt1 is a multi-functional protein implicated in key cellular processes including regulation of proliferation, survival, metabolism and protein synthesis.
Blassberg, R. A., Garza-Garcia, A., Janmohamed, A., Gates, P. B. & Brockes, J. P. Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration.
Crystal and his collaborators used the AAV approach to deliver an antibody that reduced levels of tau, a protein implicated in Alzheimer's disease, into the brains of mice with another type of dementia2.
