However, in multiple repeat experiments normalized to protein expression changes, cells expressing iKR PR consistently exhibited reduced PARP cleavage relative to cells expressing iWT PR.
Protein expression changes are not isolated events, we therefore hypothesized that differentially expressed CYB5A protein may interact with others and play a role in oncogenesis.
Selected protein expression changes were verified using Western blotting.
Status epilepticus induces a cascade of protein expression changes contributing to the subsequent development of epilepsy.
To eliminate potential bias caused by protein expression changes, all the ratios of quantifiable Kbz and Kac peptides were normalized by corresponding histone protein expression levels.
The course of the events during phagocytosis could account for the observed membrane maintenance, metabolic and cytoskeletal protein expression changes.
Based on the dendrogram, protein expression changes at stage I were distinct from those observed at stages II and III, and changes in 18R and B73 were very comparable at each stage (Fig. 4).
This trend is confirmed on datasets that assay the effect of miRNAs on mRNA and protein expression changes, and a simple linear regression model leads to significant correlation of predicted versus observed expression change.
In the postgenomic era, it has become evident that analysis of genetic and protein expression changes alone is not sufficient to understand most disease processes in e.g. cardiovascular and cancer disease.
Only protein expression changes over 30% compared to control were retained for further analysis.
This study identified a number of retinal protein expression changes with diabetes.
