JP and SYC participated in the design of the study, produced the Tat fusion protein and drafted the manuscript.
SD carried out the molecular studies, analyzed the predicted structures of the blt gene and protein, and drafted the manuscript.
RH carried out the protein studies, statistical analysis, selection of differentially expressed proteins, and drafted the manuscript.
AR carried out the bioinformatic analysis of the Sps proteins and drafted the manuscript.
JL carried out major experiments including mitochondrial purification and permeabilization, western blotting testing release of Cytochrome C and Smac proteins, and drafted the manuscript.
D.S. conceived of the transposon designs and carried out their construction, performed the transposition and screening for fluorescent fusion proteins, and drafted the manuscript.
THG extracted RNA, performed quantitative PCR, contributed to the analysis and interpretation of microarray data, analysed biological association networks and interactions between genes and proteins, and drafted the manuscript.
5HFA: 5-hydroxyferulic acid; OMT: O-methyltransferase; SAH: S-adenosyl-L-homocysteine; SAM: S-adenosyl-L-methionine RKI and JAK designed the project; EL, YP and YL constructed the 3-D model; JMZ and FKS performed the mutagenesis experiments and analyzed the mutant proteins; RKI drafted the manuscript and all co-authors participated in its editing.
IKJ performed the comparisons between evolutionary rates and the number of protein-protein interactions and drafted the manuscript.
Ross Overman performed the molecular biology, protein expression and purification, biophysical analysis, enzyme kinetics, protein crystallization and drafted the paper.
