Such large polypeptide was not detected in lysates of cultured cell lines, and its detection is probably due to the presence of cross-reacting epitopes in an unrelated protein (see Discussion).
We are grateful to Dr Milan Blake for kindly providing the E. coli strain expressing meningococcal PorB, and to Dr Paola Massari for valuable scientific advice regarding the use of this protein and discussion on data analysis.
Possibly, the effect of ChM1 varies between cell types depending on differences in cell cycle regulation and the balance of signaling pathways that can be directly or indirectly affected by the protein (see discussion above).
Since a distant, "hypoxia-inducible" expression of GLUT-1 may be expected for this HIF-1 target gene, we subsequently refer to this GLUT-1 pattern as the "inverse" type, whereas the CA IX pattern was considered "typical" for a hypoxia-regulated protein (see discussion).
To minimize the impact of these gaps, we removed from each alignment all positions in which inferred insertions were shared by less than one-third of the sequences, including all positions in front of a conserved intron [ 70] that may facilitate domain shuffling at the amino-end of the protein (see Discussion).
This result can be related to the intracellular localization of endogenous Impα/β carrier proteins (see Discussion).
These results indicate that the difference between the CC and SDC conditions cannot be explained by changing availability of G-proteins (see Discussion).
gingivalis HtpG antibodies might bind other HSP90 homologues, including human Hsp90, the P. gingivalis HtpG p18 epitope is unique and antibodies to that peptide could not be adsorbed by other HSP90 family proteins (see discussion below).
Perhaps ectopic Abd-B.r does not mediate a homeotic transformation, because it cannot suppress anterior Hox proteins (see Discussion).
These CCR4-specific amino acids are most probably relevant to functions common to and specific for all yCCR4-related proteins (see Discussion).
However, the thermodynamic parameters and stabilization mechanism from the viewpoint of equilibrium stability for the hyperstable RNases H differ depending on the proteins (see Discussion below).
