Second, the insensitivity of protein complex activity to the over-expression of subunits may have facilitated the evolution of novel protein complexes by gene duplication.
A comment on Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression.
On gene dosage balance in protein complexes: a comment on Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression.
Concering the reference http://www.biomedcentral.com/1752-0509/2/1 (i.e. Semple JI, Vavouri T, Lehner B. A simple principle concerning the robustness of protein complex activity to changes in gene expression. BMC Syst Biol. 2008 Jan 2 2 1.
Therefore we propose the following principle concerning the robustness of protein complex function to alterations in gene expression: protein complex activity in eukaryotic cells is in general robust to an increase, but not to a decrease in the expression levels of individual subunits.
Summarized transcript levels were measured for AtGL3 and the composite of all homologues for each of five B. napus trichome regulatory genes, BnGL1, BnGL2, BnGL3, BnTTG1 and BnTRY, known to be involved in MBW tri-protein complex activity in Arabidopsis.
Specifically enriched GO terms in earlywood included: cellular component organization and biogenesis, membrane, protein complex, catalytic activity, hydrolase activity and transporter activity.
The most enriched specific GO terms in juvenile wood included: cellular macromolecule metabolic process, intracellular organelle part, protein complex, hydrolase activity, and nucleotide binding; while in latewood cellular component organization and biogenesis, membrane, and transporter activity are the most enriched specific GO terms.
The APC/C is a multimeric protein complex whose activity and specificity is cell cycle regulated by interactions with co-activating factors Cdh1 and Cdc20 (Visintin et al., 1997).
From transcriptional regulation, we know enhancers and silencers of transcription; the difference in mechanics is just brought along by another kind of influence on the respective target protein complex, the activity of which is to be increased or decreased.
