Sentence examples for protein aggregate formation from inspiring English sources
Altogether, these results show that phosphorylated NBR1 does not participate in protein aggregation and this inhibits protein aggregate formation.
Analysis of the insoluble fractions from cellular/mouse models and human tissues revealed novel aggregation-prone proteins and suggests that nitrative stress contribute to protein aggregate formation in ALS.
Protein aggregate formation may be linked to a failure of the ubiquitin proteasome system (UPS) and/or the autophagy pathway.
Biochemical and cellular studies show that torsinA localizes to the endoplasmic reticulum [6], protects against oxidative stress, and prevents protein aggregate formation [5], [7], [8], [9].
Finally, characterization of tyrosine nitrated insoluble proteins showed that nitrative stress, induced by SOD1 mutation or other unknown instigation factor(s) in the case of the sporadic forms, may contribute to protein aggregate formation in ALS.
Heat shock proteins (HSPs) belong to the family of chaperone proteins and are important in refolding misfolded proteins, in preventing protein aggregate formation and targeting proteins to proteasomal degradation [10], [11].
In addition, in the hepatocytes of Atg7-deficient mice, MDB-like protein aggregates are observed [ 95], indicating that autophagy deficiency may lead to abnormal protein aggregates formation and liver injury in alcoholic hepatitis.
In physiologic conditions, coordinated expression of HS7H and HS9B stabilizes preexisting proteins against aggregate formation and they mediate correct folding and maturation of newly synthesized cellular proteins [126], [128], [129].
Our data suggest that LRRK2 inhibits the clearance of proteasome substrates upstream of proteasome catalytic activity, favouring the accumulation of proteins and aggregate formation.
Impairment of the proteasome during aging contributes to tissue damage by decreased degradation of damaged proteins thereby facilitating aggregate formation and protein toxicity [ 14, 15, 28, 30, 31].
Several lines of experimental evidence indicate that phosphorylation and nitration are likely to affect α-synuclein aggregation, although the precise relationship linking protein modifications to aggregate formation remains unclear.
