Exact(6)
A rectangular grid with 1 Å mesh size is generated around the protein, adjusted to its spatial extent.
Patients with an elevated C-reactive protein, adjusted calcium, Alk phos and GGT levels or low albumin levels were more likely to have cancer (all P<0.001).
A low albumin, an elevated mGPS, C-reactive protein, adjusted calcium, bilirubin, Alk phos, AST, ALT and GGT were associated with a reduced 5-year overall and cancer-specific survival (all P<0.001).
When investigating the cytoplasmic and nuclear fractions of proteins separately, the relative amount of HOXA4 protein (adjusted to ACTB protein levels) in the nucleus decreased with inflammatory stimulation (P = 0.0048; paired t test) in all cell types.
The regression dilution ratio of ln C reactive protein, adjusted for age and sex, was 0.57 (95% confidence interval 0.51 to 0.64), similar to those observed here for systolic blood pressure (0.51, 0.48 to 0.54), and total cholesterol (0.55, 0.52 to 0.60).
The following baseline parameters were independent predictors of radiographic progression at 1 year: baseline erosions (adjusted OR=2.29, 95% CI 1.24 to 4.24), erythrocyte sedimentation rate (adjusted OR per tertile increase=1.72, 95% CI 1.12 to 2.65) and C-reactive protein (adjusted OR per tertile increase=1.52, 95% CI 1.03 to 2.26).
Similar(54)
This resulted in a final dataset comprised of 578 proteins, for which a Linear Mixed Effects model was used to estimate the effect of population on the expression level for each protein, adjusting for colony, block and label factors.
This IS can theoretically, similar to the stable isotope-labelled protein, adjust the variation by tryptic digestion and ionisation, but the cost was much cheaper.
However, since both protein and ligand are flexible molecules, the concept is no longer adequate as during the process of molecular docking both ligand and protein adjust their conformation in order to achieve the best protein-ligand fit.
The outcome model that included the signature proteins adjusted by the clinical factors explained the survival of patients better than the model that included the clinical factors alone (likelihood-ratio test, P < 0.0033).
The results of the Swiss-Prot keyword search also identified a significant enrichment in genes annotated as PR proteins (adjusted p value = 0.002), involved in signalling (adjusted p value = 0.026) and associated with the apoplast (adjusted p value = 0.040) in list 1.
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