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In accord with these differences, we find that each CdiI protein only protects target bacteria from its cognate CdiA-CT toxin.
Indeed, some reports show that abrogating ROS production or quenching ROS almost completely protects target cells from SFR killing [ 56, 57, 77], while another [ 54] found that similar conditions granted only a partial protection.
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In particular, using self-assembling polymers to protect, target, and deliver therapeutics is a promising approach in current nanotherapeutics.
Among the non-viral vectors, nanoparticles showed remarkable properties regarding gene delivery such as the ability to target the specific tissue or cells, protect target gene against nuclease degradation, improve DNA stability, and increase the transformation efficiency or safety.
The targeted nature of an enzyme to a specific substrate plays a prominent role in selective disruption and extraction in addition to protecting target biomolecule integrity throughout the disruption process.
Second, ExMVs-producing cell lines could be transduced with genes that overexpress on the cell surface (i) peptides that protect target cells in damaged organs from apoptosis and stimulate proliferation of the residual remaining cell population (e.g., stem cell factor or Notch ligands) or (ii) factors that effectively induce angiogenesis (e.g., VEGF, FGF-2, or SDF-1) (Fig. 2b).
In addition to augmenting the expression of target proteins, CPD-His6 fusions protected target proteins from proteolytic degradation.
The need to continue treatment despite the absence of symptoms, and the significance of protecting target organs must be emphasized.
A longer observation time would have been useful to allow for better resolution between rejected and protected target cells.
This may have reduced the 'need' for inhibitory processes that are meant to protect target consolidation processes but actually cause the occurrence of an AB [11], [16].
Leucovorin acts as a reduced folate coenzyme, which is transported into, and protects mammalian host cells, but does not protect target organisms.
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